Question 1

What is the half-life of Onglyza?

Accepted Answer

The half-life of Onglyza, which contains the active ingredient saxagliptin, is the duration required for half of the drug to be cleared from the bloodstream. Research involving healthy subjects who were administered a single oral dose of 5 mg of Onglyza revealed the mean plasma terminal half-life for saxagliptin to be approximately 2.5 hours. Additionally, the active metabolite of saxagliptin exhibited a slightly longer half-life, averaging around 3.1 hours.

Question 2

Can Onglyza cause heart problems?

Accepted Answer

After reviewing various clinical studies, the Food and Drug Administration (FDA) decided to update the safety information regarding Onglyza and similar medications that contain saxagliptin and alogliptin. This updated warning highlights an increased risk of heart failure associated with these drugs. The likelihood of experiencing heart problems is particularly high in individuals who have pre-existing heart or kidney diseases. This decision by the FDA aims to inform patients and healthcare providers about the potential cardiovascular risks linked to these medications.

Question 3

Can Onglyza cause hypoglycemia?

Accepted Answer

Onglyza reduces blood sugar levels by enhancing the body’s insulin production post-meal. It generally does not cause dangerously low blood sugar levels (hypoglycemia) on its own, as its effectiveness decreases when blood sugar is low. Nonetheless, there is still a possibility of experiencing hypoglycemia when using Onglyza.

Question 4

What is the best time to take Onglyza?

Accepted Answer

Onglyza should be taken daily at about the same time. Consistently taking your tablet at the same time every day will maximize its effectiveness.

ONGLYZA

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