Question 1

Is Xigduo an SGLT2?

Accepted Answer

Yes, Xigduo is a combination medication that includes dapagliflozin and metformin. Dapagliflozin is an SGLT2 inhibitor, which blocks sodium-glucose co-transporter 2 (SGLT2) in the kidneys2. This action helps reduce glucose levels in the blood by promoting the removal of glucose through urine.

Question 2

Is Xigduo bad for kidneys?

Accepted Answer

While Xigduo is effective in managing type 2 diabetes, it has certain potential risks, especially when it comes to kidney health. The FDA has strengthened the warnings about the risk of acute or chronic kidney injury associated with dapagliflozin, one of the active ingredients in Xigduo. This is a severe condition where the kidneys stop working suddenly, which can cause a buildup of waste in the body.

Question 3

What is the best time of day to take Xigduo?

Accepted Answer

You can take Xigduo once or twice daily, with or without food. If it upsets your stomach, you can take it with food.

Question 4

Who should not take Xigduo?

Accepted Answer

This medication is contraindicated for use in: Patients with moderate to severe renal impairment Patients with a known hypersensitivity to any of the ingredients present in the product. Patients with acute or chronic metabolic acidosis Individuals with severe hepatic impairment

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